A stroke may be defined as a sudden catastrophic neurological deficit attributed to a vascular (relating to blood vessels) cause.
Strokes are classified according to etiology into ischemic and hemorrhagic stroke.
by far the most common cause of stroke constitutes 87% of all patients affected. This is caused by a block in the artery that is supplying blood to a part of the brain. Devoid of nutrition and oxygen, brain cells start to malfunction within minutes, and finally die. Hence, the neurological sequelae of a stroke are often permanent. It is estimated that 2 million brain cells die every minute. Ischaemic stroke may again be classified into thrombotic and embolic stroke depending on the exact cause of the block. Thrombotic stroke occurs when a platelet and fibrin plug is formed as the clotting factors are activated by damage to the endothelium ( internal lining of the blood vessels). Endothelial damage causes turbulence in the flow of blood thereby perpetuating a vicious cycle of more endothelial damage and platelet deposition- culminating in the formation of an intravascular (inside the artery) clot causing an arterial block. Embolic strokes usually have their origin in the heart when a blood clot in the chambers of the heart ( associated with an irregular heart beat or atrial fibrillation or a hole in the heart) detaches itself from the heart, flows along the artery and plugs one of the major arteries to the brain causing a stroke. A transient ischaemic attack is also called a mini-stroke where the blockage of an artery clears spontaneously and symptoms usually resolve in 24 hours or less. Up to 15% of people who have a mini-stroke have a major stroke within 3 months if left untreated.
This is caused by bleeding in the cranium- intracerebral hemorrhage (bleeding within the substance of the brain) is usually due to the rupture of one leash of arteries that supply the deeper structures of the brain after arising from the large arteries on the surface (the large arteries of the brain travel between the arachnoid mater and pia mater, arachnoid being the second layer of the meninges, the other two being the dura mater on the outside and the pia mater on the inside). While high blood pressure contributes of the majority of intracerebral hemorrhages other causes of bleeding include cavernous malformations ( a cluster of abnormal blood vessels lined by endothelium or the inner lining of the blood vessels, with blood flowing through them- ‘caverns’) or arterio-venous malformations or a ‘knot’ of blood vessels (abnormal communication between the arteries and veins). Bleeding from these larger arteries that are on the surface of the brain are usually due to a rupture of aneurysm ( a bubble formed on one of the arteries). This is called subarachnoid hemorrhage (SAH)
Often the first sign of ischaemic stroke is paralysis that can affect the face, arms, or leg or at times the entire half of the body. Some have trouble with speaking and speech may appear slurred. There may also be confusion, disorientation or a sudden change in behaviour. Inability to see one half of a visual field, trouble with walking and loss of balance and coordination are also common symptoms of stroke. Intracerebral hemorrhagic stroke may present with the above symptoms but headache is, more often than not, the primary complaint. If the hematoma is large, patients lose consciousness. Seizures are another presentation of stroke, and are more common in the hemorrhagic variety. Patients presenting with subarachnoid haemorrhage often present with ‘thunderclap’ headache- described by patients as the worst headache of their life. This may be accompanied by a loss of consciousness.
B – problems with Balance
E – suddend change in vision, including loss of a visual field or total blindness in one Eye
F – changes in the symmetry of the Face
A – sudden weakness of the Arms or legs
S – difficulty in speaking or garbled Speach
T – Time to call emergency service
A stroke is an emergency and the patient must be rushed to the closest medical facility. Time is a major determinant in outcome and prompt treatment saves lives and prevents long term disability due to brain damage. As we shall see later, treatments that radically improve outcome can only be administered if the patient is within a certain time window which extends for only a few hours after the onset of the first symptoms.
There are multiple medical and lifestyle factors that increase the risk of a stroke
Strokes in people under the age of 45 are often referred to as strokes in the young. While hypertension and diabetes are increasingly seen in the young these days hypercoagulable states (where the blood spontaneously clots in the blood vessels due the the absence of proteins that ensure the smooth flow of blood like Protein S and C, or the presence elevated homocysteine levels) need to be evaluated. Aneurysms, arteriovenous malformations, sickle cell disease may also present in the younger patients.
The diagnosis of stroke is made on the basis of a clinical examination, a CT/MRI scan of the brain, blood tests and investigations of the heart. While the clinical examination and the imaging of the brain make the diagnosis, it is important for the blood and heart tests to be done to be able to treat risk factors and prevent recurrence.
During the clinical examination, the doctor will ask about the history of the current episode including the use of medication and the presence of potential risk factors. This will be followed by a full physical and neurological examination. The history and examination will make the clinical diagnosis while the type of stroke (ischemic, hemorrhagic or subarachnoid) and the area of the brain affected by the stroke is confirmed by a CT or MRI scan. Blood tests are performed to rule out other contributory causes like high cholesterol, presence of infection, a hereditary tendency, increased tendency for the blood to clot and blood sugar levels. It is important to control these factors to prevent recurrence. An Echocardiogram is performed to check the functioning of the heart and rule out the possible source of an embolus originating from the heart. An ECG (Electrocardiogram) may be performed to ensure a regular cardiac rhythm, as atrial fibrillation does cause embolic strokes. In cases of a hemorrhagic stroke a cerebral angiogram may be needed to confirm/exclude the presence of arterio-venous malformation. In ischaemic stroke, a Doppler Examination of the arteries of the neck is done to rule out atheromatous narrowing (caused by deposition of cholesterol and calcium).
The management of ischemic stroke has been revolutionised by the addition of clot-busting drugs to the treatment armamentarium. These drugs such as tPA (Tissue Plasminogen Activator) have been used for clearing blockages in the heart (following a heart attack) for a long time now. When delivered within the artery causing the stroke, they break up the blood clot obstructing the flow of blood, thereby restoring the blood supply to the brain. This, if done within the 6 hour window (this varies from 4.5 -6 hrs) it can dramatically reverse the neurological deficit (paralysis).
When patients arrive outside the window period, the administration of thrombolytic drugs have had no effect. In those cases, a catheter may be inserted into the major artery and the blood clot removed mechanically – thus restoring the flow of blood- referred in medical parlance as mechanical thrombectomy. For this procedure, the window period is usually 24 hours. However, as brain cells start dying as soon as they are devoid of blood supply, time is crucial in ensuring a functional recovery.
The medical management usually starts as soon as the patient reaches the hospital. As with any critical illness, patients who are either unconscious it is vital to secure the airway and make sure that oxygen is reaching the lungs i.e. the patient is breathing spontaneously or on a ventilator and adequate blood pressure is maintained. In instances of increased blood pressure, which is the most common cause of intracerebral hemorrhage, control of blood pressure is critical in preventing the hematoma from expanding. Drugs may also be used to control brain swelling which accompanies brain tissue damage, control of diabetes and to ensure that the kidneys are working adequately. In some cases, stroke presents with seizures or with a rise in intracranial pressure when the adequate treatment of these conditions in an emergency is crucial .
Most of the care for strokes without gross neurological dysfunction is supportive. The use of blood thinning agents to prevent recurrent ischemic strokes, control of blood pressure, diabetes and dyslipidemia essential in preventing recurrence.
The role of surgery in stroke is to reduce the intracranial pressure of acute stroke or to prevent recurrent hemorrhage.
If the patient is severely disabled, it may be useful to start asking about professional home healthcare services.